17 March 2015

Publications resulting from the NCU grant 2014 (Publications only)

Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet.
Malcovati L, Hellström-Lindberg E, Bowen D, Adès L, Cermak J, Del Cañizo C, Della Porta MG, Fenaux P, Gattermann N, Germing U, Jansen JH, Mittelman M, Mufti G, Platzbecker U, Sanz GF, Selleslag D, Skov-Holm M, Stauder R, Symeonidis A, van de Loosdrecht AA, de Witte T, Cazzola M. Blood. 2013 Oct 24;122(17):2943-64
 
Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor resistent, low and INT-1 risk MDS. Results from the Nordic NMDSG08A clinical Phase 2 trial. 
Tobiasson M, Dybedahl I, Skov Holm M, Karimi M, Brandefors L, Garelius H, Grövdal M, Høgh Dufva I, Grønbæk K, Jansson M, Marcher C, Nilsson L, Olsnes A, Porwit A, Saft L, Möllgård L, Hellström-Lindberg E. Blood Cancer J. 2014 Mar 7;4:e189
 
p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)
Saft L, Karimi M, Ghaderi M, Matolscy A, Fenaux P, Mufti G, Giagounidis A, Selleslag D, Muus P, Sanz G, Mittelman M, Bowen D, Porwit A, Fu T, Backstrom J, MacBeth K, Hellström-Lindberg E. Haematologica. 2014 Jun;99(6):1041-9
 
A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine. 
Svensson T, Chowdhury O, Garelius H, Lorenz F, Saft L, Jacobsen SEJ, Hellström-Lindberg E, Cherif H. Eur J Haematol. 2014 Nov;93(5):439-45 
 
High-throughput mutational screening adds clinically important information in myelodysplastic syndromes and secondary or therapy-related acute myeloid leukemia.
Karimi M, Nilsson C, Dimitriou M, Jansson M, Matsson H, Unneberg P, Lehmann S, Kere J, Hellström-Lindberg E. Haematologica. 2015 Jun;100(6):e223-5
 
SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts. 
Malcovati L, Karimi M, Papaemmanuil E, Ambaglio I, Jädersten M, Jansson M, Elena C, Gallì A, Walldin G, Della Porta MG, Raaschou-Jensen K, Travaglino E, Kallenbach K, Pietra D, Ljungström V, Conte S, Boveri E, Invernizzi R, Rosenquist R, Campbell PJ, Cazzola M, Hellström-Lindberg E. Blood. 2015;126(2):233-41
 
Molecular characterization of melanoma cases in denmark suspected of genetic predisposition.
Wadt KA, Aoude LG, Krogh L, Sunde L, Bojesen A, Grønskov K, Wartacz N, Ek J, Tolstrup-Andersen M, Klarskov-Andersen M, Borg Å, Heegaard S, Kiilgaard JF, Hansen TV, Klein K, Jönsson G, Drzewiecki KT, Dunø M, Hayward NK, Gerdes AM. PLoS One. 2015 Mar 24;10(3):e0122662
 
Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. 
Aoude LG, Pritchard AL, ......,Gruis NA, Trent JM, Jönsson G, Bishop DT, Mann GJ, Newton-Bishop JA, Brown KM, Adams DJ, Hayward NK. J Natl Cancer Inst. 2014 Dec 13;107(2)
 
Primary melanoma tumors from CDKN2A mutation carriers do not belong to a distinct molecular subclass.
Staaf J, Harbst K, Lauss M, Ringnér M, Måsbäck A, Howlin J, Jirström K, Harland M, Zebary A, Palmer JM, Ingvar C, Olsson H, Newton-Bishop J, Hansson J, Hayward N, Gruis N, Jönsson G; Melanoma Genetics Consortium.  J Invest Dermatol. 2014 Dec;134(12):3000-3
 
A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. 
Wadt KA, Aoude LG, Johansson P, Solinas A, Pritchard A, Crainic O, Andersen MT, Kiilgaard JF, Heegaard S, Sunde L, Federspiel B, Madore J, Thompson JF, McCarthy SW, Goodwin A, Tsao H, Jönsson G, Busam K, Gupta R, Trent JM, Gerdes AM, Brown KM, Scolyer RA, Hayward NK. Clin Genet. 2014 Sep 15
 
TGF-β1-Induced Epithelial-Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells.
Johansson J, Tabor V, Wikell A, Jalkanen S, Fuxe J. Front Oncol. 2015 Jan 26;5:3
 
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.
Pang MF, Georgoudaki AM, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander JS, Nelson CM, Jakobsson L, Betsholtz C, Sund M, Karlsson MC, Fuxe J. Oncogene. 2016 Feb 11;35(6):748-60


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